Metabolic syndrome and Growth Differentiation Factor 15 in older adults
نویسندگان
چکیده
منابع مشابه
The effect of aerobic training on serum levels of Growth differentiation factor-15 and insulin resistance in elderly women with metabolic syndrome
Background and Objective: Aerobic training plays an important role in the improvement of cardiovascular-metabolic disorders associated with aging and metabolic syndrome; however, the role of this type of training on growth differentiation factor-15 (GDF-15) as a new biomarker for predicting cardiac disorders is not understood. Therefore, the purpose of the present study was to investigate the e...
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The premature GDF/PDF/MIC-1 protein consists of 308 amino acids that contain a 29 amino acid signal peptide, a 167 amino acid propeptide, and a 112 amino acid mature protein. The mature protein is secreted as a homodimer linked by disulfide bonds and is released from the propeptide following intracellular cleavage at RXXR furine-like cleavage site. The mature peptide of GDF-1/MIC-1 contains two...
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Background—Growth-differentiation factor-15 (GDF-15) is emerging as a prognostic marker in patients with cardiovascular disease (CVD), but its prognostic value in community-dwelling adults has not been reported. We hypothesized that GDF-15 would add incremental power for prediction of mortality in a population of community-dwelling older adults without known heart disease. Methods and Results—W...
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Background. Abdominal adiposity and serum leptin increase with age as does risk of metabolic syndrome. This study investigates the prospective association between leptin and metabolic syndrome risk in relation to adiposity and cytokines. Methods. The Health, Aging, and Body Composition study is a prospective cohort of older adults aged 70 to 79 years. Baseline measurements included leptin, cyto...
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the lipid part. We agree that the peroxidation of lipids present in LDL is not the only way to generate LDL oxidation. Direct oxidation of the protein moiety of the lipoprotein also occurs. The process of LDL oxidation leads to the modification of the protein moiety of LDL, either directly—via aldehydes released from endothelial cells, as Holvoet described, or via myeloperoxidase-derived hypoch...
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ژورنال
عنوان ژورنال: GeroScience
سال: 2021
ISSN: 2509-2715,2509-2723
DOI: 10.1007/s11357-021-00370-w